Tai Mei-Ling Sharon, Norhatta Norbelinda, Goh Khean Jin, Moy Foong Ming, Sujarita Ramanujam, Asraff Azman Ahmad, Lee Qin Zhi, Ng Jiun Hoong, Tan Eugene Choon Li, Mahadeva Sanjiv
Division of Neurology, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
PLoS One. 2015 Jan 28;10(1):e0115838. doi: 10.1371/journal.pone.0115838. eCollection 2015.
Dyspepsia and headache frequently co-exist, but the clinical implication of this association is uncertain. We planned to examine the prevalence and impact of dyspepsia in adults with headache.
A cross-sectional study was conducted in a secondary care setting. Clinical, psychological and health-related quality of life (HRQOL) data were compared between subjects with headache and controls (non-headache subjects). The impact of dyspepsia was analysed further in subjects with headache alone.
280 subjects (93 cases with headache and 187 matched controls) were recruited. The following baseline characteristics of subjects were as follows: mean age 45.0 ± 17.3 years, 57.0% females and ethnic distribution-Malaysian = 45 (48.4%), Chinese n = 24 (25.8%) and Indians n = 24 (25.8%). Headache sub-types among cases with headache were as follows: tension-type headache (TTH) n = 53 (57.0%) and migraine n = 40 (43.0%). Dyspepsia was more prevalent in cases with headache compared to controls (25.8% vs 12.8%, p = 0.011), and headache was independently associated with dyspepsia (OR 2.75, 95% CI 1.39-5.43). Among cases with headache, there was a trend towards a higher prevalence of dyspepsia in those with migraine (27.5%) compared to TTH (24.5%). Subjects with headache and dyspepsia, compared to those with headache alone, had a greater severity of headache symptoms (63.67 ± 22.85 mm vs 51.20 ± 24.0 mm VAS, p = 0.029). Overall HRQOL scores were lower in headache subjects with dyspepsia (EQ-5D summary score 0.82 ± 0.18 vs 0.90 ± 0.16, p = 0.037 and EQ-5D VAS 62.08 ± 17.50 mm vs 72.62 ± 18.85 mm, p = 0.018), compared to those without dyspepsia.
Dyspepsia is associated with more severe headache symptoms and results in a lower HRQOL in patients with headache.
消化不良和头痛常常同时存在，但这种关联的临床意义尚不确定。我们计划研究消化不良在成年头痛患者中的患病率及影响。
在二级医疗环境中开展一项横断面研究。比较头痛患者与对照组（无头痛受试者）的临床、心理及健康相关生活质量（HRQOL）数据。对仅患有头痛的受试者进一步分析消化不良的影响。
招募了280名受试者（93例头痛患者和187名匹配的对照组）。受试者的基线特征如下：平均年龄45.0±17.3岁，女性占57.0%，种族分布为——马来西亚人45名（48.4%），中国人24名（25.8%），印度人24名（25.8%）。头痛患者中的头痛亚型如下：紧张型头痛（TTH）53例（57.0%），偏头痛40例（43.0%）。与对照组相比，消化不良在头痛患者中更为普遍（25.8%对12.8%，p = 0.011），且头痛与消化不良独立相关（比值比2.75，95%置信区间1.39 - 5.43）。在头痛患者中，偏头痛患者（27.5%）的消化不良患病率相比紧张型头痛患者（24.5%）有升高趋势。与仅患有头痛的患者相比，患有头痛和消化不良的患者头痛症状更严重（视觉模拟评分法[VAS]63.67±22.85毫米对51.20±24.0毫米，p = 0.029）。与无消化不良的头痛患者相比，有消化不良的头痛患者总体HRQOL评分更低（EQ - 5D总结评分0.82±0.18对0.90±0.16，p = 0.037；EQ - 5D VAS 62.08±17.50毫米对72.62±18.85毫米，p = 0.018）。
消化不良与更严重的头痛症状相关，并导致头痛患者的HRQOL降低。
