Ratajska A, Fiejka E, Maksymowicz M, Gawlik Z
Department of Pathological Anatomy, Medical Academy of Warsaw, Poland.
Basic Res Cardiol. 1993 Mar-Apr;88(2):120-9. doi: 10.1007/BF00798260.
Male inbred rats (Wag) with aorto-caval fistula were used as a model of volume-overloaded heart hypertrophy. Hearts were taken after 1, 2, and 6 months postoperatively for immunohistochemical, histological and ultrastructural investigations. Immunohistochemical staining with some anti-extracellular matrix antibodies and ultrastructural findings allowed us to recognize intracardiocytic tunnels which were intracellular invaginations of plasmalemma surrounded by basement membrane. Inside the tunnels endothelial cells forming well-developed capillaries were entrapped. Tunnel capillary formation is discussed as an adaptive response to increased cardiac work due to volume overload.
将雄性近交系大鼠（Wag）制作成主动脉-腔静脉瘘模型，作为容量负荷性心肌肥大的模型。术后1个月、2个月和6个月取心脏进行免疫组织化学、组织学和超微结构研究。使用一些抗细胞外基质抗体进行免疫组织化学染色以及超微结构研究结果使我们能够识别心内细胞隧道，这些隧道是被基底膜包围的质膜的细胞内陷。在隧道内部，包埋着形成发育良好的毛细血管的内皮细胞。隧道毛细血管形成被认为是对容量负荷导致的心脏工作量增加的一种适应性反应。
