Johnson M A, McPhee T J
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Md.
Arch Ophthalmol. 1993 Jun;111(6):806-14. doi: 10.1001/archopht.1993.01090060094030.
Electroretinograms (ERGs) were recorded in 94 patients with central retinal vein occlusion (CRVO). Of these 94, 11 had neovascularization of the iris (NVI) at the time of testing, 25 later developed NVI, and 58 did not develop NVI during a follow-up period that varied from 1 1/2 to 5 years. The ERG recorded at the patient's presentation visit predicted the occurrence of NVI in these patients with high sensitivity and specificity. The most predictive ERG parameters were the semi-saturation constant from intensity-response analysis (log K), and the implicit times of the scotopic a- and b-waves and the scotopic 30-Hz flicker response. These parameters were highly correlated, suggesting that the functional mechanism that places eyes at risk for NVI in CRVO is unidimensional. Paradoxically, the most likely candidate for this mechanism is photoreceptor sensitivity loss due to ischemia.
对94例视网膜中央静脉阻塞（CRVO）患者进行了视网膜电图（ERG）记录。在这94例患者中，11例在测试时出现虹膜新生血管（NVI），25例后来发展为NVI，58例在1.5至5年不等的随访期内未发展为NVI。在患者就诊时记录的ERG对这些患者NVI的发生具有较高的敏感性和特异性预测能力。最具预测性的ERG参数是强度-反应分析中的半饱和常数（log K），以及暗视a波和b波的隐含时间和暗视30Hz闪烁反应。这些参数高度相关，表明在CRVO中使眼睛有发生NVI风险的功能机制是一维的。矛盾的是，这种机制最可能的候选因素是缺血导致的光感受器敏感性丧失。
