使用闪烁视网膜电图预测视网膜中央静脉阻塞的预后
Predicting outcome in central retinal vein occlusion using the flicker electroretinogram.
作者信息
Severns M L, Johnson M A
机构信息
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Md.
出版信息
Arch Ophthalmol. 1993 Aug;111(8):1123-30. doi: 10.1001/archopht.1993.01090080119027.
OBJECTIVE
To evaluate the usefulness of the 30-Hz flicker electroretinogram (ERG) in predicting outcome in patients with central retinal vein occlusion using an automated system previously developed to measure parameters of the flicker ERG and using information about the a priori probability of developing neovascularization of the iris in central retinal vein occlusion.
METHODS
Amplitude and timing were extracted from 30-Hz flicker ERGs of 76 patients with acute central retinal vein occlusion from a previous study. The ability of the ERG to predict the development of neovascularization of the iris based on derived parameters was measured using the area under the receiver operating characteristic curve.
RESULTS
The predictive ability of the 30-Hz ERG amplitude, as judged by a two-alternative forced-choice procedure, was 92%. The corresponding value for implicit time was 89%. Using Bayes' theorem, we computed the probability of developing neovascularization of the iris based on a single 30-Hz flicker ERG measurement at initial patient presentation.
CONCLUSIONS
The 30-Hz flicker ERG provides useful information about the patients with central retinal vein occlusion.
目的
使用先前开发的用于测量闪烁视网膜电图（ERG）参数的自动化系统，并利用视网膜中央静脉阻塞时虹膜新生血管形成的先验概率信息，评估30Hz闪烁视网膜电图（ERG）在预测视网膜中央静脉阻塞患者预后方面的效用。
方法
从先前一项研究的76例急性视网膜中央静脉阻塞患者的30Hz闪烁ERG中提取振幅和时间。使用受试者操作特征曲线下面积来测量基于导出参数的ERG预测虹膜新生血管形成发展的能力。
结果
通过二选一强制选择程序判断，30Hz ERG振幅的预测能力为92%。隐含时间的相应值为89%。使用贝叶斯定理，我们根据患者初次就诊时单次30Hz闪烁ERG测量结果计算了虹膜新生血管形成的概率。
结论
30Hz闪烁ERG可为视网膜中央静脉阻塞患者提供有用信息。
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