Johnson M A, Hood D C
Department of Ophthalmology, University of Maryland School of Medicine, Baltimore 21201-1595, USA.
J Opt Soc Am A Opt Image Sci Vis. 1996 Mar;13(3):572-6. doi: 10.1364/josaa.13.000572.
Patients with central retinal vein occlusion who later develop iris neovascularization show changes in the amplitude, the timing, and the sensitivity of the electroretinogram beta wave. We determined the extent to which rod photoreceptor dysfunction contributes to these changes by recording single-flash electroretinograms from both eyes of 52 patients with unilateral central retinal vein occlusion and fitting the leading edges of alpha waves with a model of rod phototransduction. Eyes with central retinal vein occlusion showed reductions in photoreceptor gain but no changes in photoreceptor amplitude when compared with the fellow eyes. The reductions were larger in eyes that developed iris neovascularization and were predictive of this complication. Photoreceptor gain reductions accounted for only part of the beta-wave timing delays and sensitive loss; the remainder is attributed to functional loss in the inner nuclear layer.
视网膜中央静脉阻塞后发生虹膜新生血管的患者，其视网膜电图β波的振幅、时间和敏感性会出现变化。我们通过记录52例单侧视网膜中央静脉阻塞患者双眼的单闪光视网膜电图，并将α波的前沿与视杆光转导模型拟合，来确定视杆光感受器功能障碍对这些变化的影响程度。与对侧眼相比，视网膜中央静脉阻塞眼的光感受器增益降低，但光感受器振幅无变化。在发生虹膜新生血管的眼中，这种降低更为明显，并且可预测这种并发症。光感受器增益降低仅占β波时间延迟和敏感性损失的一部分；其余部分归因于内核层的功能丧失。
