Wagner J A, Kretschmar M, Nichterlein T, Hof H, Quade B
Institute of Medical Microbiology, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Germany.
Clin Exp Immunol. 1993 Jun;92(3):473-6. doi: 10.1111/j.1365-2249.1993.tb03423.x.
Listeria monocytogenes belongs to the group of intracellular bacteria, which means that they reside and multiply within host cells. The protective immunity against such an infection is mediated by cellular immune mechanisms. Whereas the CD8+ T cell population plays a major role therein, the CD4+ T cells are held to be of minor importance in this defence system. Consequently, one can understand that immune suppression with FK 506 which acts primarily on this latter T cell subset, does not interfere with protective immunity of mice infected with L. monocytogenes. We have demonstrated that the drug blocks neither curing of primary infection, nor formation of granulomas, nor induction of cell populations capable of mediating adoptive transfer of immunity, nor expression of pre-existing immunity.
单核细胞增生李斯特菌属于细胞内细菌类别，这意味着它们在宿主细胞内生存和繁殖。针对这种感染的保护性免疫是由细胞免疫机制介导的。虽然CD8 + T细胞群体在其中起主要作用，但CD4 + T细胞在这个防御系统中被认为不太重要。因此，可以理解，主要作用于后一种T细胞亚群的FK 506免疫抑制不会干扰感染单核细胞增生李斯特菌的小鼠的保护性免疫。我们已经证明，该药物既不阻断原发性感染的治愈，也不阻断肉芽肿的形成，也不阻断能够介导免疫过继转移的细胞群体的诱导，也不阻断预先存在的免疫的表达。
