Sarciron M E, Walbaum S, Arsac C, Raynaud G, Petavy A F
Department of Parasitology, Claude-Bernard University, Lyon, France.
Am J Trop Med Hyg. 1993 May;48(5):658-65. doi: 10.4269/ajtmh.1993.48.658.
The efficacy of short- and long-term treatments with Isoprinosine, an immunomodulatory compound, was studied in Echinococcus granulosus cysts developed in NMRI mice intraperitoneally infected with sheep pulmonary cysts. After treatment, a reduction in the size and number of cysts with macroscopic modifications was observed. The structural alterations included damage or destruction of the protoscoleces and partial destruction of the cyst wall, which predominated at the inner germinal layer level. The efficacy of this drug was evaluated after long-term and short-term treatment. Short-term treatment with a dose of 1 g/kg/day gave better results, with a loss of infectivity of the larval tissue. The well-tolerated long-term treatment with a dose of 2 g/kg/day showed the absence of toxicity of this compound. The survival time of treated animals was greater than that of untreated controls.
在经腹腔接种绵羊肺囊肿而感染的NMRI小鼠体内所形成的细粒棘球绦虫囊肿中，研究了免疫调节化合物异丙肌苷短期和长期治疗的疗效。治疗后，观察到囊肿大小和数量减少，出现肉眼可见的改变。结构改变包括原头蚴的损伤或破坏以及囊肿壁的部分破坏，主要发生在内生发层水平。在长期和短期治疗后评估了该药物的疗效。剂量为1 g/kg/天的短期治疗效果更佳，幼虫组织失去感染性。剂量为2 g/kg/天的长期治疗耐受性良好，表明该化合物无毒性。治疗动物的存活时间比未治疗的对照组更长。
