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多次剂量的异丙肌苷对多房棘球绦虫幼虫的影响。

Effects of multiple doses of isoprinosine on Echinococcus multilocularis metacestodes.

作者信息

Sarciron M E, Delabre I, Walbaum S, Raynaud G, Petavy A F

机构信息

Department of Parasitology, Claude Bernard University, Lyon, France.

出版信息

Antimicrob Agents Chemother. 1992 Jan;36(1):191-4. doi: 10.1128/AAC.36.1.191.

DOI:10.1128/AAC.36.1.191
PMID:1375448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189252/
Abstract

Isoprinosine was given at daily doses of 0.5, 1, 2, and 4 g kg-1 of body weight to jirds that were infected for 3 months with Echinococcus multilocularis metacestodes. The effects of the different drug doses on metacestodes were studied by transmission electron microscopy and biochemical methods. At lower doses, increases in uric acid and adenosine deaminase activity were noted. At 4 g kg-1 of body weight, marked ultrastructural damage with metabolic perturbations was observed.

摘要

将异博定以每日0.5、1、2和4克/千克体重的剂量给予感染多房棘球绦虫幼虫3个月的沙鼠。通过透射电子显微镜和生化方法研究了不同药物剂量对幼虫的影响。在较低剂量下，观察到尿酸和腺苷脱氨酶活性增加。在4克/千克体重时，观察到明显的超微结构损伤和代谢紊乱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0d/189252/ba352799907b/aac00035-0232-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0d/189252/ba352799907b/aac00035-0232-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0d/189252/ba352799907b/aac00035-0232-a.jpg

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