Sud'ina G F, Mirzoeva O K, Pushkareva M A, Korshunova G A, Sumbatyan N V, Varfolomeev S D
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russian Federation.
FEBS Lett. 1993 Aug 23;329(1-2):21-4. doi: 10.1016/0014-5793(93)80184-v.
Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 microM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.
