Sunardhi-Widyaputra S, Van Damme B
Department of Pathology, St. Rafaël University Hospital, Faculty of Medicine Catholic University of Leuven, Belgium.
Pathol Res Pract. 1993 Mar;189(2):138-43. doi: 10.1016/S0344-0338(11)80083-X.
The presence of the extracellular matrix glycoprotein tenascin was studied immunohistochemically in normal human salivary glands and in pleomorphic adenomas. Its expression was compared to that of fibronectin, and type IV collagen. In the normal salivary gland, tenascin was found with interruptions in periductal tissues, and continuously in blood vessels, fat cells and around nerve bundles. In pleomorphic adenoma, tenascin was detected surrounding the clusters of epithelioid cells, in areas with a myxoid and a chondroid matrix, and around some myoepithelial cells as a halo. As compared to fibronectin, there is a similar location of tenascin and fibronectin around tumor cell clusters but not in myxoid and chondroid matrices. Fibronectin was found around the cells in chondroid matrix. In conclusion, tenascin is not only found in malignant tumors but also in benign tumors such as pleomorphic adenoma. The presence of tenascin as a halo around myoepithelial cells suggests a role of these cells in development of myxoid and chondroid matrices.
采用免疫组织化学方法研究了细胞外基质糖蛋白腱生蛋白在正常人类唾液腺和多形性腺瘤中的存在情况。将其表达与纤连蛋白和IV型胶原的表达进行了比较。在正常唾液腺中，腱生蛋白在导管周围组织中呈间断性分布，在血管、脂肪细胞及神经束周围呈连续性分布。在多形性腺瘤中，腱生蛋白在类上皮细胞簇周围、黏液样和软骨样基质区域以及一些肌上皮细胞周围呈晕状被检测到。与纤连蛋白相比，腱生蛋白和纤连蛋白在肿瘤细胞簇周围的分布位置相似，但在黏液样和软骨样基质中并非如此。纤连蛋白在软骨样基质中的细胞周围被发现。总之，腱生蛋白不仅存在于恶性肿瘤中，也存在于多形性腺瘤等良性肿瘤中。腱生蛋白在肌上皮细胞周围呈晕状存在提示这些细胞在黏液样和软骨样基质形成中发挥作用。
