Hao X K, Liang G D, Zhang Y H, Sun B Z, Zhou Z Y, Han J L, Wan H L, Liu W S
Department of Central Laboratory of Tangdu Hospital, Fourth Military Medical College, Xi'an.
Chin Med J (Engl). 1993 May;106(5):348-50.
Forty patients (25 cases of prostatic cancer and 15 cases of benign prostatic hyperplasia) were examined with radioimmunodetection (RAID) using antibody against r-Seminoprotein (r-Sm). The images of malignant tumor sites were revealed from the scan of single photon emission computerized tomography with the tracing of dual radionuclide and computer digital subtraction technique. Of the 25 patients with prostatic cancer tested, twenty-four were demonstrated in RAID with a positive rate of 96%. The ratio of taking in nuclide radioactivity between the tumor tissue and normal tissue (T/N) was 6.9 and the best showing time was the 96th hr from injection of radioactive antibody against r-Sm. The minimum diameter of the tumor detected in RAID was 0.5 cm. All of the 8 cases of metastatic prostatic cancer in pelvic or bone location were detected, with a rate of 100%. Of the 15 cases of benign prostatic hyperplasia, only one showed mild positive result. B-ultrasonography and CT showed a positive detective rate of 72.7% and 65%, respectively. Our results have indicated that RAID using 131I-labeled antibody against r-Sm possesses more advantages in specificity, because RAID not only defines the involved sites, but also shows the sites of the original tumors, and the metastatic location as well as the relationship between them.
对40例患者（25例前列腺癌和15例良性前列腺增生）使用抗r-精蛋白（r-Sm）抗体通过放射免疫检测（RAID）进行检查。采用双放射性核素示踪和计算机数字减法技术，通过单光子发射计算机断层扫描揭示恶性肿瘤部位的图像。在接受检测的25例前列腺癌患者中，24例在RAID中显示阳性，阳性率为96%。肿瘤组织与正常组织的核素摄取放射性比值（T/N）为6.9，最佳显示时间为注射抗r-Sm放射性抗体后的第96小时。RAID检测到的肿瘤最小直径为0.5 cm。所有8例盆腔或骨转移的前列腺癌均被检测到，检出率为100%。在15例良性前列腺增生患者中，仅1例显示轻度阳性结果。B超和CT的阳性检出率分别为72.7%和65%。我们的结果表明，使用131I标记的抗r-Sm抗体的RAID在特异性方面具有更多优势，因为RAID不仅能确定受累部位，还能显示原发肿瘤的部位、转移位置以及它们之间的关系。
