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人巨细胞病毒糖蛋白B复合体上一个中和表位的抗独特型模拟

Anti-idiotypic mimicry of a neutralizing epitope on the glycoprotein B complex of human cytomegalovirus.

作者信息

Tackaberry E S, Hamel J, Larose Y, Brodeur B R

机构信息

National Laboratory for Immunology, Laboratory Centre for Disease Control, Ottawa, Ontario, Canada.

出版信息

J Virol. 1993 Nov;67(11):6815-9. doi: 10.1128/JVI.67.11.6815-6819.1993.

DOI:10.1128/JVI.67.11.6815-6819.1993
PMID:7692085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC238124/
Abstract

Experiments were carried out to investigate the ability of rabbit anti-idiotype antibodies (Ab2), directed against an anti-human cytomegalovirus monoclonal antibody (Ab1), to induce neutralizing antibodies specific for the immunodominant glycoprotein B viral complex. Mice immunized with Ab2 produced anti-Ab2 (Ab3) that was both antigen and idiotype specific with regard to Ab1. We conclude that the Ab2 antibodies mimicked a neutralizing epitope and acted as a network antigen for inducing a specific anti-human cytomegalovirus antibody response in this experimental system.

摘要

开展实验以研究兔抗独特型抗体（Ab2）针对抗人巨细胞病毒单克隆抗体（Ab1）诱导针对免疫显性糖蛋白B病毒复合物的中和抗体的能力。用Ab2免疫的小鼠产生了抗Ab2（Ab3），其在抗原和独特型方面均对Ab1具有特异性。我们得出结论，Ab2抗体模拟了中和表位，并在该实验系统中作为网络抗原诱导特异性抗人巨细胞病毒抗体反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/8ea63437f10d/jvirol00032-0495-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/8f3a1933862b/jvirol00032-0494-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/d9dcf09cf1fc/jvirol00032-0495-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/8ea63437f10d/jvirol00032-0495-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/8f3a1933862b/jvirol00032-0494-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/d9dcf09cf1fc/jvirol00032-0495-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f253/238124/8ea63437f10d/jvirol00032-0495-b.jpg

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本文引用的文献

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Processing of the gp55-116 envelope glycoprotein complex (gB) of human cytomegalovirus.人巨细胞病毒gp55 - 116包膜糖蛋白复合体（gB）的加工过程。
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