Stríz I, Wang Y M, Teschler H, Sorg C, Costabel U
Department of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany.
Lung. 1993;171(5):293-303. doi: 10.1007/BF03215872.
The expression of maturation-associated antigens on alveolar macrophages (AMs) was studied in bronchoalveolar fluid of 30 patients with sarcoidosis and 11 control subjects. The percent of AMs expressing CD14 or CD11b (common for blood monocytes) was significantly increased in patients with active sarcoidosis compared to those with inactive disease, and control subjects. On the other hand, the mean expression of antigens characteristic for mature macrophages showed no significant difference (25F9), or was even increased in patients with sarcoidosis (CD71, KiM8). Since CD14 and CD11b molecules were also frequently expressed on large phagocytes morphologically similar to mature macrophages, and recent studies showed modulation of these glycoproteins by the activation of myeloid cells, our data indicate that the majority of AMs recovered by bronchoalveolar lavage in sarcoidosis are mature, activated cells.
在30例结节病患者和11名对照者的支气管肺泡灌洗液中，研究了肺泡巨噬细胞（AMs）上成熟相关抗原的表达。与非活动性疾病患者及对照者相比，活动性结节病患者中表达CD14或CD11b（血液单核细胞共有的）的AMs百分比显著增加。另一方面，成熟巨噬细胞特征性抗原的平均表达无显著差异（25F9），或在结节病患者中甚至增加（CD71、KiM8）。由于CD14和CD11b分子也经常在形态上与成熟巨噬细胞相似的大吞噬细胞上表达，且最近的研究表明这些糖蛋白可通过髓样细胞的激活而发生调节，我们的数据表明，结节病患者经支气管肺泡灌洗回收的大多数AMs是成熟的、活化的细胞。
