Galt S, Sandblom J, Hamnerius Y, Höjevik P, Saalman E, Nordén B
Department of Applied Electron Physics, Chalmers University of Technology, Göteborg, Sweden.
Bioelectromagnetics. 1993;14(4):315-27. doi: 10.1002/bem.2250140404.
The hypothesis that specific combinations of DC and low frequency AC magnetic fields at so-called cyclotron-resonance conditions could affect the transport of ions through ion channels, or alter the kinetics of ion channels (opening and closing rates), has been tested. As a model system, the ion channels formed by gramicidin A incorporated in lipid bilayer membranes were studied. No significant changes in channel conductance, average lifetime, or formation rate as a function of applied fields could be detected over a wide range of frequencies and field strengths. Experiments were carried out to measure the time-resolved single-channel events and the average conductances of many-channel events in the presence of K+ and H+ ions. The channel blocking effect of Ca++ was also studied.
