Williams G, Coulange C, Milroy E J, Sarramon J P, Rubben H
Department of Surgery, Hammersmith Hospital, London.
Br J Urol. 1993 Sep;72(3):335-40. doi: 10.1111/j.1464-410x.1993.tb00729.x.
Ninety-six men considered unfit for prostatic surgery underwent the insertion of a permanently implanted super alloy mesh stent (Urolume) at 5 European centres. Ninety were able to void immediately, 2 required a second stent to enable them to void and 4 voided after a period of suprapubic catheter drainage. Seven patients required the subsequent insertion of a further stent to cover the prostatic urethra completely and in 8 cases the stent was removed. Objective and symptomatic evidence of relief of bladder outflow obstruction was shown throughout the period of study. Severe irritative symptoms were seen in the majority of patients for periods of up to 3 months and resulted in removal of the stent in 3. At 12 months, 15 of 27 patients who underwent cystoscopy had complete epithelialisation of the stent and in 11 cases there was more than 70% epithelialisation. Fourteen patients developed encrustation on exposed parts of the stent during follow-up. This was associated with the development of a urinary infection in 9. The positioning of the stent in subsequent studies has been altered to overcome this problem.
96名被认为不适合进行前列腺手术的男性在欧洲5个中心接受了永久性植入的超合金网状支架（Urolume）置入术。90人术后立即能够排尿，2人需要置入第二个支架才能排尿，4人在耻骨上导管引流一段时间后排尿。7名患者需要随后再置入一个支架以完全覆盖前列腺尿道，8例患者的支架被取出。在整个研究期间，均显示出膀胱流出道梗阻缓解的客观和症状性证据。大多数患者出现了长达3个月的严重刺激性症状，3例因此取出了支架。在12个月时，接受膀胱镜检查的27名患者中有15名支架完全上皮化，11例上皮化超过70%。14名患者在随访期间支架暴露部分出现结痂。其中9例与泌尿系统感染的发生有关。在后续研究中，支架的定位已改变以克服这一问题。
