Smoller B R, Apfelberg D B
Department of Pathology, Stanford University Medical Center, CA 94305.
J Cutan Pathol. 1993 Aug;20(4):330-6. doi: 10.1111/j.1600-0560.1993.tb01271.x.
Infantile (juvenile) capillary hemangiomas are vascular neoplasms which can appear quite infiltrative histologically and are characterized by cords of cells with areas of marked cellularity. While vessels can be distinguished in most cases, there are many cells which do not appear to be endothelial in origin. We labeled 5 such cases with antibodies directed against factor VIII-related antigen, CD34, alpha actin, factor XIIIa and PC-10. Anti-factor VIII-related antigen labeled all endothelial cells and did not label cells away from vessels. Anti-CD34 recognized similar cells and also stained a subset of interstitial cells. Anti-alpha muscle defined pericytes and stained few interstitial cells and none of the endothelial cells. Many of the interstitial spindled and cuboidal cells stained strongly with anti-factor XIIIa. The majority of the mitotic activity was concentrated in the interstitial cells. These observations lend support to the concept that infantile (juvenile) capillary hemangioma is a tumor of primitive cells with capabilities for differentiating toward endothelial cells and pericytes. It is not clear whether a similar stem cell population gives rise to dermal dendrocytes, or whether these represent an immune response to the neoplasm.
婴儿（幼年型）毛细血管瘤是一种血管肿瘤，其在组织学上可表现出较强的浸润性，其特征为细胞索伴有明显的细胞密集区域。虽然在大多数情况下可以分辨出血管，但有许多细胞似乎并非起源于内皮细胞。我们用针对因子VIII相关抗原、CD34、α肌动蛋白、因子XIIIa和PC-10的抗体标记了5例此类病例。抗因子VIII相关抗原标记了所有内皮细胞，而未标记血管外的细胞。抗CD34识别出类似的细胞，并也对一部分间质细胞进行了染色。抗α肌动蛋白界定了周细胞，并对少数间质细胞进行了染色，未对任何内皮细胞染色。许多间质梭形细胞和立方形细胞被抗因子XIIIa强烈染色。大多数有丝分裂活性集中在间质细胞中。这些观察结果支持了这样一种概念，即婴儿（幼年型）毛细血管瘤是一种原始细胞肿瘤，具有向内皮细胞和周细胞分化的能力。目前尚不清楚是否有类似的干细胞群产生真皮树突状细胞，或者这些细胞是否代表对肿瘤的免疫反应。
