Parr E J, Davison S N, Davison J S, Sharkey K A
Department of Medical Physiology, University of Calgary, Alberta, Canada.
J Auton Nerv Syst. 1993 Aug-Sep;44(2-3):91-9. doi: 10.1016/0165-1838(93)90021-l.
Retrograde tracing with the fluorescent dye, Fast Blue, was used to examine the origin and distribution of neurons whose axons project through the inferior mesenteric ganglion (IMG) of the guinea-pig. These studies were performed by applying the tracer to (a) the rostral cut-end of the hypogastric nerves and (b) the caudal cut-end of the inter-mesenteric nerve (IMN). After application of tracer to the hypogastric nerves retrogradely labelled cell profiles were observed in the IMG and the superior mesenteric ganglion (SMG). The number of labelled cell profiles in the SMG was consistently about 15% of the number in the IMG. In only one of seven animals tested were labelled cells seen in the wall of the colon. Application of tracer to the IMN labelled cells in the IMG and in the wall of the colon. The distribution of the labelled enteric neurons was skewed towards the anal end of the colon. These results confirm that postganglionic sympathetic neurons in the SMG project axons through the guinea-pig IMG and describe the colonic distribution of enteric neurons that project through the IMG and into the IMN.
使用荧光染料快蓝进行逆行追踪，以检查轴突穿过豚鼠肠系膜下神经节（IMG）的神经元的起源和分布。这些研究通过将示踪剂应用于（a）腹下神经的头端切断端和（b）肠系膜间神经（IMN）的尾端切断端来进行。将示踪剂应用于腹下神经后，在IMG和肠系膜上神经节（SMG）中观察到逆行标记的细胞轮廓。SMG中标记的细胞轮廓数量始终约为IMG中的15%。在七只受试动物中，只有一只在结肠壁中看到标记细胞。将示踪剂应用于IMN可标记IMG和结肠壁中的细胞。标记的肠神经元的分布偏向结肠的肛门端。这些结果证实，SMG中的节后交感神经元通过豚鼠IMG投射轴突，并描述了通过IMG并进入IMN的肠神经元的结肠分布。
