Bruce W R, Archer M C, Corpet D E, Medline A, Minkin S, Stamp D, Yin Y, Zhang X M
Department of Medical Biophysics, University of Toronto, Ont., Canada.
Mutat Res. 1993 Nov;290(1):111-8. doi: 10.1016/0027-5107(93)90038-h.
We have used the aberrant crypt focus (ACF) assay to test and develop hypotheses linking diet and colon cancer. The hypotheses were suggested by epidemiological studies that identified possible dietary factors associated with colorectal cancer risk. The ACF assay was used to quantitate the effect of the dietary factors on the initiation and growth of these putative precursors of colon cancers in experimental animals. Using this approach we have developed 3 new hypotheses for the role of diet in colorectal cancer. These are (1) a risk associated with 5-hydroxymethyl-2-furaldehyde in caramelized sugar, (2) a risk associated with some factor in thermolyzed casein, and (3) a risk associated with single nutrient boluses of sucrose and fructose. The importance of these hypotheses has still to be tested in long term carcinogenesis experiments, in analytic epidemiology studies and then, perhaps, in intervention trials.
我们已使用异常隐窝灶（ACF）检测法来检验和提出有关饮食与结肠癌关系的假说。这些假说是由流行病学研究提出的，这些研究确定了与结直肠癌风险相关的可能饮食因素。ACF检测法用于定量饮食因素对实验动物中这些假定的结肠癌前体的起始和生长的影响。通过这种方法，我们提出了3个关于饮食在结直肠癌中作用的新假说。它们分别是：（1）与焦糖中5-羟甲基-2-糠醛相关的风险；（2）与热解酪蛋白中的某些因素相关的风险；（3）与蔗糖和果糖的单一营养素大剂量摄入相关的风险。这些假说的重要性仍有待在长期致癌实验、分析性流行病学研究中，然后或许在干预试验中进行检验。
