Chart H, van der Kar N C, Tolboom J J, Monnens L M, Rowe B
Divisions of Enteric Pathogens, Central Public Health Laboratory, London, UK.
Eur J Clin Microbiol Infect Dis. 1993 Sep;12(9):707-9. doi: 10.1007/BF02009386.
Sera from 45 patients from The Netherlands, Germany and Belgium who had a clinical diagnosis of haemolytic uraemic syndrome (HUS) were screened for antibodies to the lipopolysaccharide (LPS) of Escherichia coli producing Verocytotoxin (VTEC). Sera from 43 family contacts and 34 control patients were also examined. Using the techniques of EIA and immunoblotting, antibodies to the LPS of Escherichia coli O157 were found in 28 patients, and to the LPS of serogroups O115 and O145 in one patient and one family member respectively. The results of our study suggest that VTEC, and in particular Escherichia coli O157, might be a significant cause of HUS in Western Europe.
对来自荷兰、德国和比利时的45例临床诊断为溶血性尿毒综合征（HUS）患者的血清进行了检测，以筛查其针对产志贺毒素大肠杆菌（VTEC）脂多糖（LPS）的抗体。还检测了43名家庭接触者和34名对照患者的血清。采用酶免疫分析（EIA）和免疫印迹技术，在28例患者中发现了针对大肠杆菌O157 LPS的抗体，在1例患者和1名家庭成员中分别发现了针对O115和O145血清型LPS的抗体。我们的研究结果表明，VTEC，尤其是大肠杆菌O157，可能是西欧HUS的一个重要病因。
