Konishi Y, Kuriyama M, Mori I, Fujii Y, Konishi K, Sudo M, Ishii Y
Department of Pediatrics Fukui Medical School, Japan.
Brain Dev. 1994 Nov-Dec;16(6):450-3. doi: 10.1016/0387-7604(94)90006-x.
Local cerebral blood flow was measured in 10 high-risk infants with neonatal episodic neurological events at 41-44 post-conceptional weeks using N-isopropyl-p-[123I]iodoamphetamine (IMP) and single photon emission computed tomography (SPECT). In 5 of the 7 infants with normal neurological outcome, prominent cerebral perfusion was found in the basal ganglia, brainstem, cerebellum, parietal white matter, and sensory motor cortex. The frontal lobes showed poor relative perfusion. In 3 infants with severe neurological deficits, SPECT demonstrated severe hypoperfusion of all parts of the brain except the basal ganglia, brainstem and sensorimotor cortex. However, MRI revealed non-specific changes, such as poor myelination and ventricular dilatation. SPECT, when performed in the first weeks of life, can be useful and may be more sensitive than MRI in predicting the occurrence of major neurological handicaps. However, because of the relatively invasive character and high cost of SPECT, SPECT should not necessarily be performed in all high-risk neonates.
在孕龄41 - 44周时，使用N - 异丙基 - p - [123I]碘安非他明（IMP）和单光子发射计算机断层扫描（SPECT）对10例有新生儿发作性神经事件的高危婴儿进行了局部脑血流测量。在7例神经结局正常的婴儿中，有5例在基底神经节、脑干、小脑、顶叶白质和感觉运动皮层发现明显的脑灌注。额叶相对灌注较差。在3例有严重神经功能缺损的婴儿中，SPECT显示除基底神经节、脑干和感觉运动皮层外，大脑所有部位均有严重灌注不足。然而，MRI显示有非特异性改变，如髓鞘形成不良和脑室扩张。在生命的最初几周进行SPECT检查可能有用，并且在预测主要神经障碍的发生方面可能比MRI更敏感。然而，由于SPECT具有相对侵入性和高成本的特点，并非所有高危新生儿都必须进行SPECT检查。
