Oshima M, Suzuki C, Sasaki J, Kitoh O, Yasukochi H
Department of Radiology, Teikyo University School of Medicine.
Kaku Igaku. 1993 Jul;30(7):727-33.
Eleven newborns with suspected cerebral disease were evaluated using 123I-IMP SPECT. In a normal subject, high uptake was shown in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. Decreased perfusion was also noted in the frontal lobe. In hypoxic ischemic encephalopathy (HIE), diffuse decreased uptake which showed no redistribution in the white matter was seen in two patients. These two patients had a poor prognosis. In one of the other 4 patients with HIE, persistent defect in parasagittal area was recognized and the patient also had a poor prognosis. In one of two patients with tuberous sclerosis, 123I-IMP SPECT showed high uptake in the area of increased density shown in CT. Thus, 123I-IMP SPECT of newborn has characteristic findings different from the adult. This tracer also might have a prognostic value of clinical improvement following HIE.
对11例疑似患有脑部疾病的新生儿进行了123I-IMP单光子发射计算机断层扫描（SPECT）评估。在正常受试者中，感觉运动皮层、丘脑、中脑-脑干和小脑蚓部显示出高摄取。额叶也发现灌注减少。在缺氧缺血性脑病（HIE）中，两名患者出现弥漫性摄取减少，白质未见再分布。这两名患者预后不良。在其他4例HIE患者中，有1例矢状旁区持续存在缺损，该患者预后也不良。在2例结节性硬化症患者中，有1例123I-IMP SPECT显示在CT所示密度增加区域有高摄取。因此，新生儿的123I-IMP SPECT有不同于成人的特征性表现。这种示踪剂对HIE后的临床改善可能也具有预后价值。
