Barry A L, Fuchs P C
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Antimicrob Agents Chemother. 1995 Jan;39(1):238-40. doi: 10.1128/AAC.39.1.238.
Broth microdilution tests were carried out with 2,671 respiratory tract isolates from 19 medical centers throughout the continental United States. The tests compared a streptogramin (RP59500) to erythromycin, dirithromycin, clarithromycin, and azithromycin against Streptococcus pneumoniae, S. pyogenes, Haemophilus influenzae, and Moraxella catarrhalis. Against macrolide-susceptible strains, the potency of RP59500 was similar to that of the macrolides: the azalide, azithromycin, was two to four times more potent against H. influenzae. The azalide and three macrolides showed nearly complete cross-resistance. At 2.0 micrograms/ml or less, the streptogramin, RP59500, was active against both macrolide-resistant and -susceptible strains of S. pneumoniae (MIC for 50% of the strains tested, 0.25 microgram/ml; MIC for 90% of the strains tested, 0.5 microgram/ml).
对来自美国大陆19个医疗中心的2671株呼吸道分离菌株进行了肉汤微量稀释试验。该试验比较了一种链阳菌素（RP59500）与红霉素、地红霉素、克拉霉素和阿奇霉素对肺炎链球菌、化脓性链球菌、流感嗜血杆菌和卡他莫拉菌的抗菌活性。对于大环内酯敏感菌株，RP59500的效力与大环内酯类相似：氮杂内酯阿奇霉素对流感嗜血杆菌的效力高两到四倍。氮杂内酯和三种大环内酯类显示出几乎完全的交叉耐药性。在2.0微克/毫升或更低浓度时，链阳菌素RP59500对肺炎链球菌的大环内酯耐药和敏感菌株均有活性（50%受试菌株的MIC为0.25微克/毫升；90%受试菌株的MIC为0.5微克/毫升）。
