急性中耳炎中肺炎链球菌青霉素耐药性的体内相关因素
In vivo correlates for Streptococcus pneumoniae penicillin resistance in acute otitis media.
作者信息
Gehanno P, Lenoir G, Berche P
机构信息
Service ORL, Hôpital Bichat-Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1995 Jan;39(1):271-2. doi: 10.1128/AAC.39.1.271.
Abstract
Eighty-four children suffering from acute otitis media caused by Streptococcus pneumoniae were treated prospectively with cefuroxime axetil suspension (30 mg/kg of body weight twice daily for 8 days). The high incidence of isolates with decreased susceptibilities to penicillin (42 of 84 isolates) allowed us to establish a relationship between clinical success and the penicillin MICs for pneumococcal isolates. It was found that cefuroxime axetil is clinically effective in the treatment of acute otitis media caused by penicillin-susceptible and penicillin-intermediate strains of S. pneumoniae. The results indicate that the risk of treatment failure with cefuroxime axetil was increased in children with otitis media caused by S. pneumoniae when the penicillin MIC were greater than or equal to 2 mg/liter.
摘要
84名由肺炎链球菌引起急性中耳炎的儿童接受了头孢呋辛酯混悬液的前瞻性治疗（30mg/kg体重，每日两次，共8天）。对青霉素敏感性降低的分离株发生率较高（84株分离株中有42株），这使我们能够确定临床疗效与肺炎球菌分离株青霉素最低抑菌浓度（MIC）之间的关系。结果发现，头孢呋辛酯对青霉素敏感和青霉素中介的肺炎链球菌菌株引起的急性中耳炎临床治疗有效。结果表明，当肺炎链球菌引起中耳炎的儿童青霉素MIC大于或等于2mg/L时，使用头孢呋辛酯治疗失败的风险会增加。
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