[The interconnection between the activity of carboxypeptidase N and angiotensin-converting enzyme].

Inhibition of the angiotensin-converting enzyme by guanidino-ethylmercaptosuccinic acid, a highly specific inhibitor of carboxypeptidase H, and inhibition of carboxypeptidase H by captopril, a highly specific inhibitor of the angiotensin-converting enzyme, in vivo were studied. Guanidinoethylmercaptosuccinic acid and captopril had no effect either on the angiotensin-converting enzyme or the carboxypeptidase H activities in vitro. The putative mechanisms of the inhibitors effects of the enzyme activity are discussed.