Vernigora A N, Nikishin N N, Gengin M T
Biokhimiia. 1995 Jan;60(1):144-9.
Inhibition of the angiotensin-converting enzyme by guanidino-ethylmercaptosuccinic acid, a highly specific inhibitor of carboxypeptidase H, and inhibition of carboxypeptidase H by captopril, a highly specific inhibitor of the angiotensin-converting enzyme, in vivo were studied. Guanidinoethylmercaptosuccinic acid and captopril had no effect either on the angiotensin-converting enzyme or the carboxypeptidase H activities in vitro. The putative mechanisms of the inhibitors effects of the enzyme activity are discussed.
研究了羧肽酶H的高度特异性抑制剂胍基乙硫基琥珀酸对血管紧张素转换酶的抑制作用，以及血管紧张素转换酶的高度特异性抑制剂卡托普利对羧肽酶H的抑制作用。胍基乙硫基琥珀酸和卡托普利在体外对血管紧张素转换酶或羧肽酶H的活性均无影响。文中讨论了抑制剂对酶活性影响的可能机制。
