Gross P
Arch Environ Health. 1976 Mar-Apr;31(2):101-7. doi: 10.1080/00039896.1976.10667199.
Data obtained from animal models of fiber glass pneumoconiosis in which the fiber glass dust was inhaled indicate that fiber glass dust is nonfibrogenic and should be classified as a nuisance-type dust. Fiber glass dust, when inhaled even in high concentrations during much of the animal's lifetime, does not stimulate the production of neoplastic tissue. Epidemiologic data and pathologic examination of the lungs of long-term fiber glass workers indicate that fiber glass dust evokes no recognizable anatomic or functional changes. The development of tumors in the chest and abdominal cavities of rats as a result of the implantation of mineral fibers of diverse composition, including glass, has no relevance to man. The implication derived from such experimental results in rats that inhaled glass fibers are potentially carcinogenic for man, is therefore an inappropriate extrapolation of misinterpreted data.
从吸入玻璃纤维粉尘的动物模型中获得的数据表明，玻璃纤维粉尘不具有致纤维化性，应归类为公害型粉尘。即使在动物的大部分生命期内高浓度吸入玻璃纤维粉尘，也不会刺激肿瘤组织的产生。长期从事玻璃纤维工作的工人的流行病学数据和肺部病理检查表明，玻璃纤维粉尘不会引起可识别的解剖学或功能变化。大鼠胸腔和腹腔内由于植入包括玻璃在内的各种成分的矿物纤维而产生肿瘤，这与人类无关。因此，从大鼠的此类实验结果得出吸入玻璃纤维对人类有潜在致癌性的结论，是对错误解释的数据进行的不恰当推断。
