Nozoe S, Naruo T, Yonekura R, Nakabeppu Y, Soejima Y, Nagai N, Nakajo M, Tanaka H
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Brain Res Bull. 1995;36(3):251-5. doi: 10.1016/0361-9230(94)00199-b.
We used single photon emission computed tomography (SPECT) with Tc-99m-HMPAO to examine the characteristics of regional cerebral blood flow (rCBF) in five patients with bulimia nervosa (BN), eight patients with anorexia nervosa (AN), and in nine healthy controls. The SPECT examinations were performed before and after food intake stimulus, and the values of the corrected ratio (R) for rCBF in 10 cerebral cortical regions before (Rbefore) and after eating (Rafter) were calculated. The asymmetry indices (AI) of the R values for the left and right side of each cortical region and the percent change from Rbefore to Rafter (%change) were computed. In comparison with the other two groups, BN patients showed significantly higher Rbefore values in the bilateral inferior frontal and left temporal regions. The AN patients showed significantly lower Rbefore values in the left parietal region than the control group. There were no significant differences in Rafter values among the three groups. The %change values in the AN group showed the greatest increase in 9 out of the 10 regions. In contrast to the positive values obtained from the 10 regions observed in the AN group, 5 out of the 10 regions in the BN group showed negative values. Among the three groups, significant differences in %change were observed on both sides of the inferior frontal, temporal, parietal, and occipital regions. These findings indicate that differences in cerebral function of BN and AN patients can be characterized through SPECT imaging.
我们使用锝-99m-六甲基丙烯胺肟单光子发射计算机断层扫描（SPECT）来检查5例神经性贪食症（BN）患者、8例神经性厌食症（AN）患者以及9名健康对照者的局部脑血流（rCBF）特征。在食物摄入刺激前后进行SPECT检查，并计算10个脑皮质区域进食前（Rbefore）和进食后（Rafter）rCBF的校正比值（R）。计算每个皮质区域左右两侧R值的不对称指数（AI）以及从Rbefore到Rafter的百分比变化（%change）。与其他两组相比，BN患者双侧额下回和左侧颞区的Rbefore值显著更高。AN患者左侧顶叶区域的Rbefore值显著低于对照组。三组之间的Rafter值没有显著差异。AN组的%change值在10个区域中的9个区域显示出最大的增加。与AN组观察到的10个区域获得的正值相反，BN组10个区域中的5个区域显示出负值。在三组中，额下回、颞叶、顶叶和枕叶区域两侧的%change存在显著差异。这些发现表明，BN和AN患者的脑功能差异可以通过SPECT成像来表征。
