淋巴细胞亚群向发炎阑尾的选择性募集。
Selective recruitment of lymphocyte subsets to the inflamed appendix.
作者信息
Soo K S, Michie C A, Baker S R, Wyllie J H, Beverley P C
机构信息
Department of Surgery, University College London Medical School, UK.
出版信息
Clin Exp Immunol. 1995 Apr;100(1):133-8. doi: 10.1111/j.1365-2249.1995.tb03614.x.
Total lymphocyte counts and the distribution of lymphocyte subsets were determined in peripheral venous blood and appendiceal mononuclear cells from 60 patients who underwent appendicectomy for the clinical diagnosis of appendicitis. A significant peripheral lymphopenia was observed in the 46 patients with histologically confirmed acute appendicitis which was accompanied by an increase in the appendiceal lymphocyte concentration. There was an even greater depletion of CD45RO+ (memory) T lymphocytes in peripheral blood and an increase in the inflamed appendix. Reciprocal changes were observed in the CD45RA+ (naive) T lymphocyte subset. These changes were reflected in the local arterial and venous CD45RA and CD45RO T lymphocyte subsets. Proliferation studies showed an expanded functional repertoire of T lymphocytes in the inflamed appendix. Selective recruitment of memory T lymphocytes from the peripheral blood to the inflamed appendix was demonstrated.
对60例因临床诊断为阑尾炎而接受阑尾切除术的患者，测定其外周静脉血和阑尾单个核细胞中的总淋巴细胞计数及淋巴细胞亚群分布。在46例经组织学证实为急性阑尾炎的患者中观察到明显的外周淋巴细胞减少，同时阑尾淋巴细胞浓度增加。外周血中CD45RO+（记忆）T淋巴细胞的耗竭更为明显，而在发炎的阑尾中则增加。在CD45RA+（初始）T淋巴细胞亚群中观察到相反的变化。这些变化反映在局部动脉和静脉的CD45RA和CD45RO T淋巴细胞亚群中。增殖研究表明，发炎阑尾中的T淋巴细胞功能谱扩大。证实了记忆T淋巴细胞从外周血选择性募集到发炎的阑尾中。
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