Durand J M, Lefevre P, Kaplanski G, Casanova P, Soubeyrand J
Department of Internal Medicine, CHU Sainte-Marguerite, Marseille, France.
Clin Rheumatol. 1994 Dec;13(4):635-40. doi: 10.1007/BF02243009.
We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertension and nephroangiosclerosis might indeed be one of the complications associated with anticardiolipin antibodies. The mechanism responsible might be the interaction of anticardiolipin antibodies, platelets and endothelial cell leading to microthrombi formation and increased local mitogenic activity that attract and stimulate neighbouring smooth muscle cell and fibroblast proliferation.
我们描述了两名患有原发性抗磷脂综合征且伴有严重高血压的患者。肾活检标本提供了肾内血管疾病的组织学证据，表现为血管内微血栓形成和肾硬化，无增殖性肾小球病变特征。恶性高血压和肾血管硬化可能确实是抗心磷脂抗体相关的并发症之一。其潜在机制可能是抗心磷脂抗体、血小板和内皮细胞之间的相互作用，导致微血栓形成以及局部促有丝分裂活性增加，进而吸引并刺激邻近平滑肌细胞和成纤维细胞增殖。
