酒精和吸烟对英国中年男性血铅水平的影响。
Effects of alcohol and smoking on blood lead in middle-aged British men.
作者信息
Shaper A G, Pocock S J, Walker M, Wale C J, Clayton B, Delves H T, Hinks L
出版信息
Br Med J (Clin Res Ed). 1982 Jan 30;284(6312):299-302. doi: 10.1136/bmj.284.6312.299.
Abstract
A survey of middle-aged men in 24 British towns showed a strong association between blood lead concentrations, alcohol consumption, and cigarette smoking. The association with alcohol persisted after age, social class, body mass index, cigarette smoking, water lead concentrations, and the town of residence had been taken into account. There was an independent but less pronounced association between cigarette smoking and blood lead concentrations after adjustment for the other factors. The possible mechanisms include a decreased excretion of lead due to alcohol-induced hepatic dysfunction and an increased lead intake from cigarette smoking. These findings have implications for widespread measurement of blood lead concentrations in adults in the community and for all studies attempting to relate blood lead concentrations to environmental exposure.
摘要
一项对英国24个城镇中年男性的调查显示，血铅浓度、饮酒量和吸烟之间存在紧密联系。在考虑了年龄、社会阶层、体重指数、吸烟情况、水中铅浓度以及居住城镇等因素后，饮酒与血铅浓度的关联依然存在。在对其他因素进行调整后，吸烟与血铅浓度之间存在独立但不太显著的关联。可能的机制包括酒精引起的肝功能障碍导致铅排泄减少，以及吸烟导致铅摄入量增加。这些发现对于社区中成年人血铅浓度的广泛测量以及所有试图将血铅浓度与环境暴露联系起来的研究都具有启示意义。
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