Kato T, Fukatsu H, Ito K, Tadokoro M, Ota T, Ikeda M, Isomura T, Ito S, Nishino M, Ishigaki T
Department of Radiology, Nagoya University School of Medicine, Japan.
Eur J Nucl Med. 1995 Jan;22(1):32-9. doi: 10.1007/BF00997245.
The aim of this study was to examine the significance and problems of 2-[fluorine-18]-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in diagnosing pancreatic cancer and mass-forming pancreatitis (MFP). PET, X-ray computed tomography (CT) and magnetic resonance (MR) imaging were performed in 15 patients with pancreatic cancer and nine patients with MFP. The areas of the PET scan were determined according to the markers drawn on the patients at CT or MR imaging. Regions of interests (ROIs) were placed by reference to the CT or MR images corresponding to the PET images. Tissue metabolism was evaluated by the differential absorption ratio (DAR) at 50 min after intravenous injection of FDG [DAR = tissue tracer concentration/(injected dose/body weight). The DAR value differed significantly in pancreatic cancer (mean +/- SD, 4.64 +/- 1.94) and MFP (mean +/- SD, 2.84 +/- 2.22) (P < 0.05). In one false-negative case (mucinous adenocarcinoma), the tumour contained a small number of malignant cells. In one false-positive case, lymphocytes accumulated densely in the mass in the pancreatic head. Further studies are necessary to investigate the histopathological characteristics (especially the cellularity) and other factors affecting the FDG DAR on PET images.
本研究的目的是探讨2-[氟-18]-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）在诊断胰腺癌和肿块型胰腺炎（MFP）中的意义及问题。对15例胰腺癌患者和9例MFP患者进行了PET、X线计算机断层扫描（CT）和磁共振（MR）成像检查。PET扫描区域根据CT或MR成像时在患者身上标记的位置确定。通过参考与PET图像对应的CT或MR图像来放置感兴趣区（ROI）。静脉注射FDG 50分钟后，通过差异吸收率（DAR）评估组织代谢[DAR = 组织示踪剂浓度/（注射剂量/体重）]。胰腺癌（均值±标准差，4.64±1.94）和MFP（均值±标准差，2.84±2.22）的DAR值差异有统计学意义（P < 0.05）。在1例假阴性病例（黏液腺癌）中，肿瘤内恶性细胞数量较少。在1例假阳性病例中，胰头部肿块内淋巴细胞密集聚集。有必要进一步研究PET图像上影响FDG DAR的组织病理学特征（尤其是细胞密度）及其他因素。
