惊厥剂3-巯基丙酸可降低大鼠胰岛和大脑中γ-氨基丁酸（GABA）和谷氨酸脱羧酶（GAD）的水平。
A convulsant, 3-mercaptopropionic acid, decreases the level of GABA and GAD in rat pancreatic islets and brain.
作者信息
Katoh J, Taniguchi H, Ogura M, Kasuga M, Okada Y
机构信息
Department of Internal Medicine, Hyogo Rehabilitation Center, Kobe, Japan.
出版信息
Experientia. 1995 Mar 15;51(3):217-9. doi: 10.1007/BF01931099.
To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after intraperitoneal administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg. 60 min after the administration of 3-MP, GABA concentration in the hypothalamus, the superior colliculus and the hippocampus of the brain decreased by 20-30% and in the pancreatic islets by 35%. The concentration in the pancreatic acini did not change. Western blotting showed that GAD activity in the pancreatic islets decreased after administration of 3-MP compared to the control. The activity of GAD in the pancreatic islets as well as brain can be modified by a convulsant, in this case 3-MP. These results suggest the properties of GAD may be similar in the pancreatic islets and brain.
为研究大鼠脑和胰岛中γ-氨基丁酸（GABA）合成酶谷氨酸脱羧酶（GAD）的特性，腹腔注射25mg/kg的3-巯基丙酸（3-MP）后，测定脑和胰岛中的GABA浓度。注射3-MP 60分钟后，脑的下丘脑、上丘和海马中的GABA浓度降低了20%-30%，胰岛中的GABA浓度降低了35%。胰腺腺泡中的浓度没有变化。蛋白质免疫印迹法显示，与对照组相比，注射3-MP后胰岛中的GAD活性降低。惊厥剂3-MP可改变胰岛以及脑中GAD的活性。这些结果表明，胰岛和脑中GAD的特性可能相似。
Zotero 插件