Ren L, Yasuda M, Nonaka S, Shiokawa S, Wada T, Nobunaga M
Department of Clinical Immunology, Medical Institute of Bioregulation, Kyushu University, Oita, Japan.
Fukuoka Igaku Zasshi. 1995 Jan;86(1):6-11.
The effects of the extract of Tripterygium wilfordii. (TWE) on experimental adjuvant arthritis (AA) in the rat was studied. Lewis rats induced with AA were administered with TWE at 50 mg/kg/day for 10 weeks. The paw volume, its ratio to the body weight (paw ratio) and the radiologic changes in the feet of the rats with AA taking TWE were compared with those in the rats taking indomethacin (0.5 mg/kg/day) and no additional drugs. The rats taking TWE showed a smaller paw volume, a lower paw ratio and milder radiologic changes than the rats taking no drugs, however, the beneficial effects were weaker than those of indomethacin. We concluded that the beneficial effects of TWE on rats with AA was suggested. However, these results still need to be further confirmed by additional experiments.
研究了雷公藤提取物（TWE）对大鼠实验性佐剂性关节炎（AA）的影响。用AA诱导的Lewis大鼠，以50mg/kg/天的剂量给予TWE，持续10周。将服用TWE的AA大鼠的爪体积、其与体重的比值（爪比值）以及足部的放射学变化，与服用吲哚美辛（0.5mg/kg/天）和未服用其他药物的大鼠进行比较。服用TWE的大鼠与未服药的大鼠相比，爪体积更小、爪比值更低且放射学变化更轻，然而，其有益作用比吲哚美辛弱。我们得出结论，提示TWE对AA大鼠有有益作用。然而，这些结果仍需通过额外实验进一步证实。
