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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Yu K T, Nuss G, Boyce R, Jariwala N, Owens G, Pennetti A, Chan W, Zhang D C, Chang M N, Zilberstein A

Department of Inflammation/Bone Metabolism, Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426.

Gen Pharmacol. 1994 Oct;25(6):1115-22. doi: 10.1016/0306-3623(94)90126-0.

It was investigated whether an extract of Tripterygium wilfordii Hook f (TW) inhibits IL-1 production by monocytes and suppresses the development of IL-1-dependent arthritis induced in rats with streptococcal cell wall and adjuvant. 2. TW preferentially inhibited IL-1 alpha and IL-1 beta production by bacterial lipopolysaccharide (LPS)-stimulated human monocytes with IC50 of approximately 1 microgram/ml. 3. Oral administration of TW dose-dependently suppressed joint swelling and structural damage in streptococcal cell wall-induced arthritis (ED50 = 20 mg/kg/day) and in adjuvant-induced arthritis (ED50 = 46 mg/kg/day for developing and 8 mg/kg/day for established arthritis).

Yu K T, Nuss G, Boyce R, Jariwala N, Owens G, Pennetti A, Chan W, Zhang D C, Chang M N, Zilberstein A

Department of Inflammation/Bone Metabolism, Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426.

Gen Pharmacol. 1994 Oct;25(6):1115-22. doi: 10.1016/0306-3623(94)90126-0.

It was investigated whether an extract of Tripterygium wilfordii Hook f (TW) inhibits IL-1 production by monocytes and suppresses the development of IL-1-dependent arthritis induced in rats with streptococcal cell wall and adjuvant. 2. TW preferentially inhibited IL-1 alpha and IL-1 beta production by bacterial lipopolysaccharide (LPS)-stimulated human monocytes with IC50 of approximately 1 microgram/ml. 3. Oral administration of TW dose-dependently suppressed joint swelling and structural damage in streptococcal cell wall-induced arthritis (ED50 = 20 mg/kg/day) and in adjuvant-induced arthritis (ED50 = 46 mg/kg/day for developing and 8 mg/kg/day for established arthritis).