Hayward M J, Roy R B
Br J Vener Dis. 1976 Feb;52(1):63-4. doi: 10.1136/sti.52.1.63.
A comparison has been made of the efficiency of a 2-day course of metronidazole (Flagyl) with that of a similar course of nimorazole (Naxogin) in the treatment of trichomoniasis. Of the 105 consecutive patients treated, 72 were finally included in the study (38 on metronidazole and 34 on nimorazole). Follow-up tests indicated an overall cure rate of 84-3 per cent. in those given Flagyl and 85-3 per cent. in those given Naxogin. Consorts were treated in just over 55 per cent. of cases in both groups. An attempt has been made to classify the recurrences as either 'primary' treatment failures or re-infections. Although both drugs were effective in the majority of cases, 'primary' treatment failure appeared to be commoner in the group receiving metronidazole. It is emphasized that the total dose of metronidazole was substantially lower than that recommended by the manufacturers.
已对甲硝唑（灭滴灵）两日疗程与硝唑咪（纳索金）类似疗程治疗滴虫病的疗效进行了比较。在连续治疗的105例患者中，最终72例纳入研究（38例接受甲硝唑治疗，34例接受硝唑咪治疗）。随访检查表明，接受灭滴灵治疗者的总治愈率为84.3%，接受纳索金治疗者为85.3%。两组中伴侣接受治疗的病例均略多于55%。已尝试将复发病例分为“原发性”治疗失败或再次感染。虽然两种药物在大多数病例中均有效，但“原发性”治疗失败在接受甲硝唑治疗的组中似乎更为常见。需强调的是，甲硝唑的总剂量大大低于制造商推荐的剂量。
