Roy R B, Laird S M, Heasman L
Br J Vener Dis. 1975 Aug;51(4):281-4. doi: 10.1136/sti.51.4.281.
The effectiveness of metronidazole (Flagyl) and nimorazole (Naxogin) has been compared by using these drugs in the recommended dosage in alternate patients in a series of 218 consecutive cases of vaginal trichomoniasis. Follow-up tests in 100 patients treated with metronidazole and 97 treated with nimorazole indicated cure-rates of 95 and 82 per cent. respectively. Male consorts were examined and given treatment on epidemiological grounds in about 70 per cent. of both treatment groups. Both drugs were free from significant side-effects. The causes of treatment failure in trichomoniasis are discussed and the desirability of relating dosage to the patient's body-weight is suggested. This factor may be especially important in deciding the dosage given on epidemiological grounds to the male consorts. It may also be an important advantage in the current trend of treating trichomoniasis in both sexes with larger doses over a much shorter time.
在218例连续的阴道毛滴虫病患者中，对交替使用甲硝唑（灭滴灵）和硝咪唑（纳索金）的推荐剂量的疗效进行了比较。对100例接受甲硝唑治疗的患者和97例接受硝咪唑治疗的患者进行的随访测试表明，治愈率分别为95%和82%。两个治疗组中约70%的男性配偶根据流行病学情况接受了检查和治疗。两种药物均无明显副作用。讨论了滴虫病治疗失败的原因，并建议根据患者体重确定剂量。在根据流行病学情况确定男性配偶的给药剂量时，这一因素可能尤为重要。在目前男女均使用大剂量且疗程短得多的趋势下，这也可能是一个重要优势。
