散发性肌萎缩侧索硬化症中红细胞铜/锌超氧化物歧化酶活性

Red blood cell Cu/Zn superoxide dismutase activity in sporadic amyotrophic lateral sclerosis.

作者信息

Puymirat J, Cossette L, Gosselin F, Bouchard J P

机构信息

Department of Medicine and Molecular Genetics, CHU Laval, Sainte-Foy, Quebec, Canada.

出版信息

J Neurol Sci. 1994 Dec 1;127(1):121-3. doi: 10.1016/0022-510x(94)90145-7.

DOI:10.1016/0022-510x(94)90145-7

PMID:7699387

Abstract

To determine the possible role of Cu/Zn superoxide dismutase (SOD1) in the pathophysiology of sporadic amyotrophic lateral sclerosis (SALS), we measured SOD1 activity in red blood cell lysates in patients with SALS. SOD1 activity in red blood cell lysates was independent of age and sex in control patients, and no significant difference was found between the levels of SOD1 activity in controls (1174.8 +/- 213, n = 29) and SALS patients (1203.4 +/- 214, n = 27). These results suggest that point mutations in the SOD1 gene are apparently unrelated to SALS.

摘要

为了确定铜/锌超氧化物歧化酶（SOD1）在散发性肌萎缩侧索硬化症（SALS）病理生理学中的可能作用，我们检测了SALS患者红细胞裂解物中的SOD1活性。在对照患者中，红细胞裂解物中的SOD1活性与年龄和性别无关，并且在对照组（1174.8 +/- 213，n = 29）和SALS患者（1203.4 +/- 214，n = 27）的SOD1活性水平之间未发现显著差异。这些结果表明，SOD1基因中的点突变显然与SALS无关。