颞下颌关节紊乱病患者滑液中的肿瘤坏死因子
Tumor necrosis factor in synovial fluid of patients with temporomandibular disorders.
作者信息
Fu K, Ma X, Zhang Z, Chen W
机构信息
Department of Oral and Maxillofacial Surgery, School of Stomatology, Beijing Medical University, China.
出版信息
J Oral Maxillofac Surg. 1995 Apr;53(4):424-6. doi: 10.1016/0278-2391(95)90717-3.
PURPOSE
To assess tumor necrosis factor (TNF) activity in synovial fluid from patients with temporomandibular disorders.
PATIENTS AND METHODS
Tumor necrosis factor (TNF) activity in synovial fluid from 27 patients with temporomandibular disorders (TMDs) was studied using the MTT tetrazolium WEHI 164 clone 13 cell cytotoxicity assay.
RESULTS
No detectable TNF levels were found in five patients with a masticatory muscle disorder, but elevated TNF levels were found in 5 of 11 patients with TMJ disc displacement, and in 9 of 11 patients with degenerative joint disease.
CONCLUSION
The findings of biologically active TNF in the synovial fluid of these patients suggests that it may play a role in the pathogenesis of certain temporomandibular disorders.
目的
评估颞下颌关节紊乱病患者滑液中肿瘤坏死因子（TNF）的活性。
患者与方法
采用MTT四氮唑WEHI 164克隆13细胞毒性试验，研究27例颞下颌关节紊乱病（TMD）患者滑液中肿瘤坏死因子（TNF）的活性。
结果
11例咀嚼肌紊乱患者中有5例未检测到TNF水平，但11例颞下颌关节盘移位患者中有5例以及11例退行性关节病患者中有9例TNF水平升高。
结论
这些患者滑液中存在具有生物活性的TNF，提示其可能在某些颞下颌关节紊乱病的发病机制中起作用。
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