Mogi M, Harada M, Kondo T, Riederer P, Inagaki H, Minami M, Nagatsu T
Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan.
Neurosci Lett. 1994 Oct 24;180(2):147-50. doi: 10.1016/0304-3940(94)90508-8.
Interleukin (IL)-1 beta, IL-6, epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha) were measured for the first time in the brain (caudate nucleus, putamen and cerebral cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme immunoassays. The concentrations of IL-1 beta, IL-6, EGF, and TGF-alpha in the dopaminergic, striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex did not show significant differences between parkinsonian and control subjects. Since these cytokines and growth factors may play important roles as neurotrophic factors in the brain, the present results suggest that they may be produced as compensatory responses in the nigrostriatal dopaminergic regions in Parkinson's disease, and may be related, at least in part, to the process of neurodegeneration in Parkinson's disease.
通过高灵敏度夹心酶免疫测定法，首次在对照组和帕金森病患者的大脑（尾状核、壳核和大脑皮层）中检测白细胞介素（IL）-1β、IL-6、表皮生长因子（EGF）和转化生长因子-α（TGF-α）。帕金森病患者多巴胺能纹状体区域中IL-1β、IL-6、EGF和TGF-α的浓度显著高于对照组，而大脑皮层中帕金森病患者与对照组之间未显示出显著差异。由于这些细胞因子和生长因子可能在大脑中作为神经营养因子发挥重要作用，目前的结果表明，它们可能是帕金森病黑质纹状体多巴胺能区域的代偿性反应产物，并且可能至少部分与帕金森病的神经退行性变过程有关。
