Delaney C A, Mouser J V, Westerman R A
Department of Physiology, Monash University, Clayton, Vic., Australia.
Neurosci Lett. 1994 Oct 24;180(2):277-80. doi: 10.1016/0304-3940(94)90538-x.
The direct effect of reduced insulin sensitivity (measured by insulin tolerance test and fasting plasma insulin) on sensory nerve function was examined in non-diabetic human subjects. Thermal sensation (measured by warm and cold perception thresholds) deteriorated with fasting hyperinsulinaemia in the presence of normoglycaemia and normal glucose tolerance. The results suggest a possible role for insulin in sensory nerve function, also that deficits in insulin action per se may adversely affect the function of small sensory nerves independent of glycaemic levels, and may thus be implicated in the aetiology of diabetic neuropathy.
在非糖尿病受试者中，研究了胰岛素敏感性降低（通过胰岛素耐量试验和空腹血浆胰岛素测定）对感觉神经功能的直接影响。在血糖正常和葡萄糖耐量正常的情况下，热感觉（通过冷热感知阈值测量）随着空腹高胰岛素血症而恶化。结果表明胰岛素在感觉神经功能中可能发挥作用，胰岛素作用本身的缺陷可能独立于血糖水平而对小感觉神经的功能产生不利影响，因此可能与糖尿病神经病变的病因有关。
