Zimonjic D B, Alimandi M, Miki T, Popescu N C, Kraus M H
Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Oncogene. 1995 Mar 16;10(6):1235-7.
The HER4/erbB-4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine kinases and has been reported to encode a receptor for NDF/heregulin. In the present study we determined the chromosomal location of the HER4/erbB-4 gene within the human genome. Using human cDNA probes in fluorescence in situ hybridization (FISH), we mapped the HER4/erbB-4 gene to human chromosome 2q33.3-34. This finding established that also the HER4/erbB-4 gene is located in close vicinity of homeobox and collagen gene loci, as is the case for the related EGFR, erbB-2/neu and erbB-3. Aberrations of this chromosomal region associated with T cell leukemias and lymphomas as well as alveolar rhabdomyosarcomas raise the possibility that HER4/erbB-4 might be activated in these tumour types.
HER4/erbB-4基因已被分离出来，作为人类酪氨酸激酶EGFR亚家族的第四个成员，据报道它编码NDF/heregulin的一种受体。在本研究中，我们确定了HER4/erbB-4基因在人类基因组中的染色体定位。利用人cDNA探针进行荧光原位杂交（FISH），我们将HER4/erbB-4基因定位到人类染色体2q33.3-34。这一发现表明，HER4/erbB-4基因也位于同源框和胶原蛋白基因位点附近，相关的EGFR、erbB-2/neu和erbB-3也是如此。与T细胞白血病、淋巴瘤以及肺泡横纹肌肉瘤相关的该染色体区域畸变，增加了HER4/erbB-4可能在这些肿瘤类型中被激活的可能性。
