Buko V U, Nemkevich V V, Mal'tsev A N, Nikitin V S, Malyshko I A, Ignatenko K V, Shumakher R
Patol Fiziol Eksp Ter. 1994 Oct-Dec(4):50-3.
The paper deals with studies into the mechanism of hepatoprotective action of essential phospholipids (EP) in chronic alcohol intoxication. EPs reduce the count of hepatocytes with hypotopic and fatty dystrophic signs, normalize hepatic triglycerides. The EP antioxidative effect found is associated with vitamin E admixture in the preparation. EPs reduce the level of cAMP and the activity of adenylate cyclase. The activity of cAMP-dependent protein kinase becomes normal only with high doses of EP (300 mg/kg). It is suggested that the hepatoprotective effect of EP may be manifested through normalization of the cAMP-dependent transduction of a signal, resulting in stabilization of hepatic metabolic processes.
本文探讨了必需磷脂（EP）在慢性酒精中毒中肝保护作用的机制。EP可减少出现位置异常和脂肪营养不良体征的肝细胞数量，使肝脏甘油三酯水平正常化。所发现的EP抗氧化作用与制剂中混合的维生素E有关。EP可降低cAMP水平和腺苷酸环化酶的活性。仅在高剂量EP（300mg/kg）时，cAMP依赖性蛋白激酶的活性才恢复正常。提示EP的肝保护作用可能通过cAMP依赖性信号转导的正常化来体现，从而稳定肝脏代谢过程。
