Kimbrough R, LeVois M, Webb D
Institute for Evaluating Health Risks, Washington, DC 20005-3521, USA.
Pediatrics. 1995 Apr;95(4):550-4.
To test the hypothesis that elevated lead in soil is positively correlated with blood lead (BPb) levels in children in an urban population surrounding a closed lead smelter, a US Environmental Protection Agency Superfund clean-up site was surveyed.
A total of 827 volunteers including 490 children under 6 years of age participated. A questionnaire was administered. Blood lead was determined as was lead content of samples of house dust, soil, paint, and water of the participants' homes.
The arithmetic mean venous BPb in 490 children between 6 and 72 months of age was 6.9 micrograms/dL (0.33 mumol/L) range 0.7 to 40.2 micrograms/dL (0.03 to 1.94 mumol/L). The BPb of 78 (16%) children in this group was > or = 10 micrograms/dL (0.48 mumol/L). Based on multiple regression modeling, lead in house dust accounted for 18% of the variance in BPb. Lead in paint together with the condition of the house were the main contributors to the dust lead variance (26%) with soil lead accounting for an additional 6%. Lead in paint alone accounted for 3% of the BPb variance. Lead in paint together with the condition of the house accounted for 12% of BPb variance, and lead in soil accounted for an additional 3%. Factors other than environmental lead such as education of parents, household income, and behavior were associated with BPb levels.
The mean BPb in children was below the present level of concern of the Centers for Disease Control and Prevention. Children with BPb of > or = 10 micrograms/L (0.48 mumol/L) tended to live in poorly maintained older houses. Based on these findings lead in soil and paint in well-maintained homes contributed little to the lead exposure of children.
为验证在一个围绕着已关闭铅冶炼厂的城市人口中,土壤中铅含量升高与儿童血铅(BPb)水平呈正相关这一假设,对美国环境保护局超级基金清理场地进行了调查。
共有827名志愿者参与,其中包括490名6岁以下儿童。进行了问卷调查。测定了血铅水平以及参与者家中房屋灰尘、土壤、油漆和水样本中的铅含量。
490名6至72个月大儿童的算术平均静脉血BPb为6.9微克/分升(0.33微摩尔/升),范围为0.7至40.2微克/分升(0.03至1.94微摩尔/升)。该组中78名(16%)儿童的BPb≥10微克/分升(0.48微摩尔/升)。基于多元回归模型,房屋灰尘中的铅占BPb变异的18%。油漆中的铅以及房屋状况是灰尘铅变异的主要因素(26%),土壤铅额外占6%。仅油漆中的铅占BPb变异的3%。油漆中的铅与房屋状况共同占BPb变异的12%,土壤中的铅额外占3%。除环境铅外的其他因素,如父母教育程度、家庭收入和行为,与BPb水平相关。
儿童的平均BPb低于疾病控制与预防中心目前关注的水平。BPb≥10微克/升(0.48微摩尔/升)的儿童往往居住在维护不善的旧房屋中。基于这些发现,维护良好的房屋中的土壤和油漆对儿童铅暴露的贡献很小。