[1991年至1993年在墨西哥分离出的24526株霍乱弧菌O1的抗生素耐药模式]

[Antibiotic resistance pattern of 24, 526 strains of Vibrio cholerae O1 isolated in Mexico from 1991 to 1993].

作者信息

Giono-Cerezo S, Zárate A, Gutiérrez L, Valdespino J L

机构信息

Laboratorio de Bacteriologia Entérica, Instituto Nacional de Diagnóstico y Referencia Epidemiológicos, México, D.F., Mexico.

出版信息

Rev Latinoam Microbiol. 1994 Oct-Dec;36(4):257-62.

PMID:7701135

Abstract

Profile of antimicrobial resistance by Kirby-Bauer method was performed on 24526 Vibrio cholerae O1 strains isolated in México (1991-1993) from fecal swabs in cholera cases and from asymptomatic carriers. Minimal inhibitory concentration (MIC) tests for tetracycline (Te) and doxycycline (D) were done on selected strains. Single antibiotic discs were used at concentrations of: Te, 30 micrograms; D, 30 micrograms; erythromycin (E), 15 micrograms; chloramphenicol (CM), 30 micrograms; ampicillin (AM), 10 micrograms; trimethoprim-sulfamethoxazole (SXT) 1.25 micrograms/23.75 micrograms. Strains whose halos were of a smaller diameter than the intermediate value were considered resistant. It is important to maintain surveillance on antimicrobial susceptibility as epidemiological marker on geographical selected areas in order to detect changes of resistant patterns.

摘要

采用 Kirby-Bauer 方法对 1991 年至 1993 年在墨西哥从霍乱病例的粪便拭子和无症状携带者中分离出的 24526 株霍乱弧菌 O1 菌株进行了抗菌药物耐药性分析。对选定菌株进行了四环素（Te）和强力霉素（D）的最低抑菌浓度（MIC）测试。使用的单种抗生素纸片浓度为：Te，30 微克；D，30 微克；红霉素（E），15 微克；氯霉素（CM），30 微克；氨苄青霉素（AM），10 微克；甲氧苄啶 - 磺胺甲恶唑（SXT）1.25 微克/23.75 微克。光环直径小于中间值的菌株被视为耐药。为了检测耐药模式的变化，在地理选定区域将抗菌药物敏感性作为流行病学标志物进行监测很重要。