小核仁核糖核蛋白颗粒的诞生：核糖核酸酶MRP与真核生物前体核糖体RNA加工系统的进化

Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system.

作者信息

Morrissey J P, Tollervey D

机构信息

European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

出版信息

Trends Biochem Sci. 1995 Feb;20(2):78-82. doi: 10.1016/s0968-0004(00)88962-8.

DOI:10.1016/s0968-0004(00)88962-8

PMID:7701567

Abstract

The ribonucleoprotein particle RNase MRP is required for the processing of yeast pre-ribosomal RNA (pre-rRNA). A structurally related particle, RNase P, is universally required for processing of pre-tRNA, but in bacteria and archaea also cleaves a site in the pre-rRNA. This suggests that RNase MRP may have arisen in eukaryotes as a form of RNase P specialized for pre-rRNA processing. Other eukaryotic small nucleolar RNAs may have arisen as trans-acting factors that functionally replace cis-acting pre-rRNA interactions in bacteria and archaea.

摘要

核糖核蛋白颗粒RNase MRP是酵母前核糖体RNA（pre-rRNA）加工所必需的。一种结构相关的颗粒RNase P是前体tRNA加工普遍需要的，但在细菌和古细菌中也能切割前体rRNA中的一个位点。这表明RNase MRP可能在真核生物中作为一种专门用于前体rRNA加工的RNase P形式出现。其他真核生物小核仁RNA可能作为反式作用因子出现，在功能上取代了细菌和古细菌中顺式作用的前体rRNA相互作用。