Mdurvwa E G, Ogunbiyi P O, Gakou H S, Reddy P G
Department of Microbiology, School of Veterinary Medicine, Tuskegee University, Alabama 36088.
Vet Res Commun. 1994;18(6):483-90. doi: 10.1007/BF01839425.
Goats infected with caprine arthritis-encephalitis virus (CAEV) show chronic arthritis and cachexia, which are progressive in nature. The immunopathogenic mechanisms responsible for these progressive clinical symptoms have not been fully elucidated. Various haematological and immunological parameters were evaluated in experimentally-infected goats showing typical signs of CAEV-induced disease. Infected goats showed recurrent lymphocytosis that may be due to constant presentation of antigen by infected cells of a monocyte/macrophage lineage. The serum alkaline phosphatase and gamma-glutamyl transferase concentrations were elevated in infected goats, a characteristic of hepatic and bone disorders. All other serum chemistry parameters were similar between infected and control goats. Importantly, the serum tumour necrosis factor-alpha (TNF-alpha) levels were higher in infected goats. The cachexia seen in infected goats may be at least partly due to altered metabolism as a result of prolonged elevation of serum TNF-alpha levels. Depressed natural killer cell activity was observed in infected goats and may contribute towards the establishment of a persistent infection with CAEV.
感染山羊关节炎-脑炎病毒（CAEV）的山羊会出现慢性关节炎和恶病质，且这些病症呈进行性发展。导致这些进行性临床症状的免疫致病机制尚未完全阐明。对表现出CAEV诱导疾病典型症状的实验感染山羊的各种血液学和免疫学参数进行了评估。感染山羊出现反复淋巴细胞增多，这可能是由于单核细胞/巨噬细胞谱系的感染细胞持续呈递抗原所致。感染山羊的血清碱性磷酸酶和γ-谷氨酰转移酶浓度升高，这是肝脏和骨骼疾病的特征。感染山羊和对照山羊之间的所有其他血清化学参数相似。重要的是，感染山羊的血清肿瘤坏死因子-α（TNF-α）水平较高。感染山羊出现的恶病质可能至少部分是由于血清TNF-α水平长期升高导致代谢改变所致。在感染山羊中观察到自然杀伤细胞活性降低，这可能有助于建立CAEV的持续感染。
