Lähdevirta J, Maury C P, Teppo A M, Repo H
Medical Department, Aurora Hospital, Helsinki, Finland.
Am J Med. 1988 Sep;85(3):289-91. doi: 10.1016/0002-9343(88)90576-1.
In order to evaluate the relationship between cachectin/tumor necrosis factor (TNF) and cachexia in the acquired immunodeficiency syndrome (AIDS), we studied the serum levels of endogenous cachectin/TNF in subjects with human immunodeficiency virus (HIV) infection.
Fifty-three serum samples were obtained from 39 HIV-seropositive patients. The condition of each patient was clinically classified as either asymptomatic, lymphadenopathy syndrome (LAS), AIDS-related complex (ARC), or AIDS. Control sera were obtained from 29 healthy male blood donors. A double antibody radioimmunoassay was used to measure the serum levels of cachectin/TNF.
Cachectin/TNF levels were within the reference range of the control values in all (eight of eight) asymptomatic HIV-infected subjects and in 11 of 13 of the patients with LAS. In contrast, all patients with AIDS (nine of nine) and five of nine of the patients with ARC had raised levels of cachectin/TNF. Fluctuation of the levels of cachectin/TNF occurred during follow-up, but initially raised levels remained elevated.
Since cachectin/TNF suppresses lipoprotein lipase in adipocytes in vitro, and causes weight loss under experimental conditions, the findings of raised levels of cachectin/TNF in patients with AIDS may have relevance to the pathogenesis of cachexia.
为了评估恶病质素/肿瘤坏死因子（TNF）与获得性免疫缺陷综合征（AIDS）中的恶病质之间的关系，我们研究了人类免疫缺陷病毒（HIV）感染患者体内内源性恶病质素/TNF的血清水平。
从39例HIV血清阳性患者中获取了53份血清样本。每位患者的病情根据临床分为无症状、淋巴结病综合征（LAS）、艾滋病相关综合征（ARC）或艾滋病。对照血清取自29名健康男性献血者。采用双抗体放射免疫分析法测定血清恶病质素/TNF水平。
所有（8例中的8例）无症状HIV感染受试者以及13例LAS患者中的11例，其恶病质素/TNF水平在对照值的参考范围内。相比之下，所有艾滋病患者（9例中的9例）以及ARC患者中的9例中的5例，其恶病质素/TNF水平升高。恶病质素/TNF水平在随访期间出现波动，但最初升高的水平仍维持在高位。
由于恶病质素/TNF在体外可抑制脂肪细胞中的脂蛋白脂肪酶，并在实验条件下导致体重减轻，AIDS患者中恶病质素/TNF水平升高的发现可能与恶病质的发病机制有关。
