Wharton K A
Division of Biology and Medicine, Brown University, Providence, RI 02912.
Bioessays. 1995 Jan;17(1):13-6. doi: 10.1002/bies.950170105.
Three recent reports identify two genes, thick veins (tkv) and saxophone (sax), which encode serine/threonine transmembrane proteins that act as receptors for mediating different aspects of the Drosophila TGF-beta-related signal, dpp. tkv is required for patterning the entire embryonic dorsal region, while sax is required for patterning only amnioserosa, the dorsalmost cell fates. dpp signaling in other developmental processes again requires both tkv and sax, but to differing degrees. tkv and sax encode type I receptors, which appear to directly bind ligand, unlike what has been observed for other type I receptors.
最近的三项报告鉴定出了两个基因，粗脉（tkv）和萨克斯风（sax），它们编码丝氨酸/苏氨酸跨膜蛋白，这些蛋白作为受体介导果蝇转化生长因子β相关信号dpp的不同方面。tkv是整个胚胎背侧区域模式形成所必需的，而sax仅对浆膜（最背侧的细胞命运）的模式形成是必需的。在其他发育过程中，dpp信号传导同样需要tkv和sax，但程度不同。tkv和sax编码I型受体，与其他I型受体不同，它们似乎直接结合配体。
