小配体选择性结合对DNA螺旋-线圈转变影响的理论思考。
A theoretical consideration of the influence of selective binding of small ligands on DNA helix-coil transition.
机构信息
Institute of Bioorganic Chemistry, Belarus Academy of Sciences, Minsk, Belarus.
出版信息
J Biomol Struct Dyn. 1994 Oct;12(2):343-54. doi: 10.1080/07391102.1994.10508744.
Abstract
The influence of small ligands on DNA helix-coil transition is considered theoretically. The ligands are supposed to interact with DNA base pairs reversibly and selectively. The long-range ligand-ligand interactions are taken into account. Simple formulae are derived for calculation of melting curve alteration induced by ligand binding. The proposed theoretical approach requires neither knowledge of nucleotide sequence nor long computation time.
摘要
从理论上考虑了小分子配体对DNA螺旋-线圈转变的影响。假定这些配体与DNA碱基对可逆且选择性地相互作用。考虑了配体-配体之间的长程相互作用。推导了用于计算由配体结合引起的熔解曲线变化的简单公式。所提出的理论方法既不需要核苷酸序列的知识，也不需要长时间的计算。
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