[The effect of ligands undergoing temperature conformational transitions on the stability of DNA double helix].

The influence of ligands, which undergo conformational transition, on DNA molecular melting is considered theoretically. Equations for computation of melting curves of DNA included in such complexes are obtained, which are used for studies of DNA double helix stability and of the binding to helical and coil regions influence on ligand conformational transitions. Calculated melting curves and experimental data for DNA-RNAase complex are compared.