小鼠系统性鼠麻风分枝杆菌感染：肝脏、脾脏和骨髓中倍增时间的差异以及一种测量接种物中活生物体比例的方法。
Systemic Mycobacterium lepraemurium infection in mice: differences in doubling time in liver, spleen, and bone marrow, and a method for measuring the proportion of viable organisms in an inoculum.
作者信息
Brown I N, Krenzien H N
出版信息
Infect Immun. 1976 Feb;13(2):480-6. doi: 10.1128/iai.13.2.480-486.1976.
Abstract
Counts of acid-fast bacilli were made on homogenates of whole liver, whole spleen, and two femurs of CBA mice killed at various time intervals after intravenous infection with Mycobacterium lepraemurium. The growth curves so obtained showed that the bacillus multiplied faster in bone marrow than in liver or spleen. No evidence of redistribution during the early part of infection was obtained. The time of appearance of significant numbers of bacilli (10(7)) in the bone marrow was used to make estimates of viability of M. lepraemurium suspensions. Several applications of the techniques described are discussed.
摘要
对静脉注射感染鼠麻风杆菌后在不同时间间隔处死的CBA小鼠的全肝、全脾和两根股骨匀浆进行抗酸杆菌计数。由此获得的生长曲线表明，该杆菌在骨髓中的繁殖速度比在肝脏或脾脏中更快。在感染早期未发现重新分布的证据。利用骨髓中出现大量杆菌（10⁷）的时间来估计鼠麻风杆菌悬液的活力。讨论了所述技术的几种应用。
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